Article

HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1

2024-06-02

Abstract excerpt

<h4>ABSTRACT</h4> We previously reported that hepatitis C virus (HCV) infection or HCV core protein expression induces HOX gene expression by impairing histone H2A monoubiquitination via a proteasome-dependent reduction in the level of RNF2, a key catalytic component of polycomb repressive complex 1 (PRC1) (J. Virol, 2021, 95, e01784-20). In this study, we aimed to investigate the mechanism by which HCV infection...

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Literature Corpus work: c78e9249-676f-554c-b45f-6bfbe24ecba9
DOI: 10.1101/2024.06.02.596761

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