Article
A pre-neoplastic epigenetic field defect in HCV-infected liver at transcription factor binding sites and polycomb targets.
Oncogene - 6 Apr 2017
Wijetunga N A, Pascual M, Tozour J, Delahaye F, Alani M, Adeyeye M, Wolkoff A W, Verma A, Greally J M
Abstract excerpt
The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) involves components of viral infection, inflammation and time. The development of multifocal, genetically distinct tumours is suggestive of a field defect affecting the entire liver. The molecular susceptibility mediating such a field defect is not understood. One potential mediator of long-term cellular...
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