Article

RNA-Binding Protein NF90 Mediates Polycomb-Independent Transactivation by EZH2 to Promote Cancer Growth

2025-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Increasing evidence suggests critical roles of the polycomb-independent transactivation function of EZH2 in promoting some cancers, such as prostate cancer (PCa), yet the underlying mechanism remains poorly understood. Here, we identify the RNA-binding protein NF90 as a key mediator of this activity. NF90 interacts with EZH2, but not with other core components of the polycomb repressive complex...

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Literature Corpus work: 36e79b07-6098-59d5-bcb8-776c665bfa1e
DOI: 10.64898/2025.12.02.691892

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