Mutational signatures in hematological malignancies.

Abstract excerpt

The set of somatic mutations present in a human tumor is a record of one or more mutational processes, each of which leaves distinct "signature" of mutation types. Mutation types can be classified in various ways, the most straightforward being the base change induced by a single-base substitution (e.g., C>A, T>G, etc.). The advent of high-throughput DNA sequencing has facilitated the comprehensive, genome-wide...

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