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Portrait of a cancer: mutational signature analyses for cancer diagnostics

15 May 2019

Abstract excerpt

BACKGROUND: In the past decade, systematic and comprehensive analyses of cancer genomes have identified cancer driver genes and revealed unprecedented insight into the molecular mechanisms underlying the initiation and progression of cancer. These studies illustrate that although every cancer has a unique genetic make-up, there are only a limited number of mechanisms that shape the mutational landscapes of cancer...

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PMID: 31092228
DOI: 10.1186/s12885-019-5677-2

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