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Article

Bioinformatic Methods to Identify Mutational Signatures in Cancer.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Islam S M Ashiqul, Alexandrov Ludmil B

Abstract excerpt

The genome of a cancer contains somatic mutations that reflect the activities of endogenous and exogenous mutational processes, with each mutational process imprinting a characteristic mutational signature. Computational analysis of somatic mutations derived from next-generation sequencing data allows revealing the mutational signatures operative in a set of cancer genomes. In this chapter, we briefly review the...

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PMID: 33165866
DOI: 10.1007/978-1-0716-0810-4_28

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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