Article

Genome-wide association study of treatment resistant depression highlights shared biology with metabolic traits

2022-08-11

Abstract excerpt

Treatment resistant depression (TRD), often defined by absence of symptomatic remission following at least two adequate treatment trials, occurs in roughly a third of all individuals with major depressive disorder (MDD). Prior work has suggested a significant common variant genetic component of liability to TRD, with heritability estimates of 8% when comparing to non-treatment resistant MDD. Despite this evidence...

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Literature Corpus work: c7884c79-7ea0-5cd9-9579-e8e8e2f11c8f
DOI: 10.1101/2022.08.10.22278630

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