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Article

Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits.

The American journal of psychiatry - 1 Jul 2024

Kang JooEun, Castro Victor M, Ripperger Michael, Venkatesh Sanan, Burstein David, Linnér Richard Karlsson, Rocha Daniel B, Hu Yirui, Wilimitis Drew, Morley Theodore, Han Lide, Kim Rachel Youngjung, Feng Yen-Chen Anne, Ge Tian, Heckers Stephan, Voloudakis Georgios, Chabris Christopher, Roussos Panos, McCoy Thomas H, Walsh Colin G, Perlis Roy H, Ruderfer Douglas M

Abstract excerpt

OBJECTIVE: Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear....

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PMID: 38745458
DOI: 10.1176/appi.ajp.20230247

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