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Article

Treatment-resistant depression: role of genetic factors in the perspective of clinical stratification and treatment personalisation.

Molecular psychiatry - 1 May 2025

Fabbri Chiara

Abstract excerpt

Treatment-resistant depression (TRD) is associated with chronic depression, suicidal behaviours, and reduced quality of life. TRD has a demonstrated genetic component, estimated around 8% based on common genetic variation in unrelated individuals. However, only six genome-wide association studies of TRD were published, and no replicated signals at locus or gene level have been identified; furthermore, apparently...

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PMID: 39827221
DOI: 10.1038/s41380-025-02899-0

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TRD

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