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Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposing

22 Jun 2021

Abstract excerpt

Major depressive disorder (MDD) is the single largest contributor to global disability and up to 20-30% of patients do not respond to at least two antidepressants (treatment-resistant depression, TRD). This study leveraged imputed gene expression in TRD to perform a drug repurposing analysis. Among those with MDD, we defined TRD as having at least two antidepressant switches according to primary care records in...

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PMID: 34158615
DOI: 10.1038/s41386-021-01059-6

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