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Article

Role of the Pharmacogenomics in the Treatment-Resistant Depression: A Literature Review

2025-09-30

Abstract excerpt

<h4>Background: </h4> Treatment-resistant depression (TRD) affects up to 30–40% of patients with major depressive disorder and remains a major therapeutic challenge. Genetic and epigenetic factors are increasingly recognized as key contributors to both vulnerability and treatment response. <h4>Methods:</h4> We conducted a narrative review of studies published between 2021 and 2025, focusing exclusively on DNA- and...

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Literature Corpus work
2eea69ba-3285-53aa-886a-3fb6fb350487
DOI
10.20944/preprints202509.2347.v1
Open publication

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