Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping.

Translational psychiatry - 3 Feb 2020

Fabbri Chiara, Kasper Siegfried, Kautzky Alexander, Zohar Joseph, Souery Daniel, Montgomery Stuart, Albani Diego, Forloni Gianluigi, Ferentinos Panagiotis, Rujescu Dan, Mendlewicz Julien, Uher Rudolf, Lewis Cathryn M, Serretti Alessandro

Abstract excerpt

Treatment-resistant depression (TRD) occurs in ~30% of patients with major depressive disorder (MDD) but the genetics of TRD was previously poorly investigated. Whole exome sequencing and genome-wide genotyping were available in 1209 MDD patients after quality control. Antidepressant response was compared to non-response to one treatment and non-response to two or more treatments (TRD). Differences in the risk of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Depression
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 32066715
DOI: 10.1038/s41398-020-0738-5
PMCID: PMC7026437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping.PMID 32066715Read ↗

A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotypingSemantic proximity Read ↗

Genome-wide association study of treatment resistant depression highlights shared biology with metabolic traitsSemantic proximity Read ↗

Exploring depression treatment response by using polygenic risk scoring across diverse populations.Semantic proximity Read ↗

Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits.Semantic proximity Read ↗

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis.Semantic proximity Read ↗

Genetic Landscape of Major Depressive Disorder: Assessment of Potential Diagnostic and Antidepressant Response MarkersSemantic proximity Read ↗

Genetic Correlates of Treatment-Resistant Depression: Insights from Polygenic Scores Across Cognitive, Temperamental, and Sleep Traits in the All of US cohortSemantic proximity Read ↗

Role of the Pharmacogenomics in the Treatment-Resistant Depression: A Literature ReviewSemantic proximity Read ↗

Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohortsSemantic proximity Read ↗

Transcriptome-wide association study of treatment-resistant depression and depression subtypes for drug repurposingSemantic proximity Read ↗

Exome-wide screening identifies novel rare risk variants for major depression disorder.Semantic proximity Read ↗

Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.