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Article

Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail Approach

2023-05-30

Abstract excerpt

The inter-individual variability of CYP450s enzyme activity may be reduced by comparing the effects of bariatric surgery on CYP-mediated drug elimination in comparable patients before and after surgery. The current research will use a low-dose phenotyping cocktail to simultaneously evaluate the activities of six CYP isoforms and P-gp.The results showed that following weight reduction after surgery, the activity of...

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Literature Corpus work
c7716111-4ab1-5f2d-b094-3c0bb3da869a
DOI
10.20944/preprints202305.2120.v1
Open publication

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Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail ApproachDOI 10.20944/preprints202305.2120.v1
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