Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after intensifying treatment regimen using Geneva cocktail.

doi:10.1111/bcpt.13840

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Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after intensifying treatment regimen using Geneva cocktail.

Basic & clinical pharmacology & toxicology - 1 Jun 2023

Neyshaburinezhad Navid, Shirzad Nooshin, Rouini Mohammadreza, Namazi Soha, Khoshayand Mohammadreza, Esteghamati Alireza, Nakhjavani Manouchehr, Ghasim Hengameh, Gloor Yvonne, Daali Youssef, Ardakani Yalda H

Abstract excerpt

The present study evaluates the influence of type 2 diabetes (T2D) on important CYP450 (CYP) isoforms and P-glycoprotein (Pgp) transporter activities before and 3 months after an intensifying treatment regimen involving 40 patients. Results have been compared with 21 non-T2D healthy participants (the control group). CYPs and Pgp activities were assessed after administering the Geneva cocktail. The mean metabolic...

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PMID: 36734157
DOI: 10.1111/bcpt.13840

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