Article
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2020
Krogstad Veronica, Peric Alexandra, Robertsen Ida, Kringen Marianne K, Wegler Christine, Angeles Philip Carlo, Hjelmesæth Jøran, Karlsson Cecilia, Andersson Shalini, Artursson Per, Åsberg Anders, Andersson Tommy B, Christensen Hege
Abstract excerpt
The liver and small intestine restrict oral bioavailability of drugs and constitute the main sites of pharmacokinetic drug-drug interactions. Hence, detailed data on hepatic and intestinal activities of drug metabolizing enzymes is important for modeling drug disposition and optimizing pharmacotherapy in different patient populations. The aim of this study was to determine the activities of seven cytochrome P450...
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