Article

Evaluation of important human CYP450 isoforms and P-glycoprotein phenotype changes and genotype in type 2 diabetic patients, before and after treatment, by using Geneva cocktail

2022-12-05

Abstract excerpt

The present study evaluates the influence of type 2 diabetes (T2D) on important CYP450 isoforms and P-glycoprotein (P-gp) transporter activities before and 3 months after intensifying treatment regimen of 40 patients. Results have been compared with 21 non-T2D healthy participants (control group). CYPs and P-gp activities were assessed after administration of Geneva cocktail. Mean metabolic ratios (MR) for CYP2B6...

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Literature Corpus work: 38acaf1d-3be2-57b2-9f6c-7fb02eb425d4
DOI: 10.22541/au.167025244.46141774/v1

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