Article
In vivo Phenotyping Methods: Cytochrome P450 Probes with Emphasis on the Cocktail Approach.
Current pharmaceutical design - 1 Jan 2017
Keller Guillermo Alberto, Gago María Laura Ferreirós, Diez Roberto Alejandro, Di Girolamo Guillermo
Abstract excerpt
BACKGROUND: Differences in drug response among patients are common. Most major drugs are effective in only 25 to 60 percent of the patients, in part due to the CYP enzymes, whose activity vary up to 50-fold between individuals for some index metabolic reactions. Several factors affect CYP activity, among which genetic polymorphisms have been studied as the major cause for long time. Age, gender, disease states,...
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