Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail.

Clinical pharmacology and therapeutics - 1 Jun 2021

Lenoir Camille, Daali Youssef, Rollason Victoria, Curtin François, Gloor Yvonne, Bosilkovska Marija, Walder Bernhard, Gabay Cem, Nissen Michael John, Desmeules Jules Alexandre, Hannouche Didier, Samer Caroline Flora

Abstract excerpt

Cytochromes P450 (CYP) are subject to important interindividual variability in their activity due to genetic and environmental factors and some diseases. Limited human data support the idea that inflammation downregulates CYP activities. Our study aimed to evaluate the impact of orthopedic surgery (acute inflammation model) on the activity of six human CYP. This prospective observational study was conducted in 30...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C-Reactive Protein
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Combinations

Share to Inflammation Mediators

Share to Interleukin-6

Share to Isoenzymes

Share to Postoperative Complications

Source

Open in PubMed Open full text

Identifiers

PMID: 33341941
DOI: 10.1002/cpt.2146
PMCID: PMC8247903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of Acute Inflammation on Cytochromes P450 Activity Assessed by the Geneva Cocktail.PMID 33341941Read ↗

Impact of SARS-CoV-2 Infection (COVID-19) on Cytochromes P450 Activity Assessed by the Geneva Cocktail.Semantic proximity Read ↗

Impact of SARS-CoV-2 infection (COVID-19) on cytochromes P450 activity assessed by the Geneva cocktail.Semantic proximity Read ↗

Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail ApproachSemantic proximity Read ↗

Distinct Effects of Inflammation on Cytochrome P450 Regulation and Drug Metabolism: Lessons from Experimental Models and a Potential Role for PharmacogeneticsSemantic proximity Read ↗

Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins.Semantic proximity Read ↗

Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.Semantic proximity Read ↗

An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.Semantic proximity Read ↗

A Phenotyping Tool for Seven Cytochrome P450 Enzymes and Two Transporters: Application to Examine the Effects of Clopidogrel and Gemfibrozil.Semantic proximity Read ↗

Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.Semantic proximity Read ↗

Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method.Semantic proximity Read ↗

An Explorative Study of CYP2D6's Polymorphism in a Sample of Chronic Pain Patients.Semantic proximity Read ↗

CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.