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Article

Evaluation of drug-metabolizing enzyme hydroxylation phenotypes in Hispanic populations: the CEIBA cocktail.

Drug metabolism and drug interactions - 1 Jan 2013

de Andrés Fernando, Sosa-Macías Martha, Lazalde-Ramos Blanca P, Naranjo María Eugenia G, Tarazona-Santos Eduardo, Llerena Adrián

Abstract excerpt

Interindividual differences in response to drug treatments are mainly caused by differences in drug metabolism, in which cytochrome P450 (CYP450) enzymes are involved. Genetic polymorphisms of these enzymes have a key role in this variability. However, environmental factors, endogenous metabolism and disease states also have a great influence on the actual drug metabolism rate (metabolic phenotype). Consequently,...

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Share to Cytochrome P-450 Enzyme System
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23787463
DOI: 10.1515/dmdi-2013-0020

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