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Article

The role of type II deiodinase polymorphisms in clinical management of hypothyroid patients treated with levothyroxine.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 May 2013

Al-azzam S I, Alkhateeb A M, Al-Azzeh O, Alzoubi K H, Khabour O F

Abstract excerpt

STUDY OBJECTIVE: Several factors can affect achieving the goals with levothyroxine (L-T4) therapy. This study investigates the clinical and biochemical response to L-T4 replacement therapy in hypothyroid patients in correlation with genetic variation in Deiodinase type || (DIO2) gene. DESIGN AND SETTING: This is a cross-sectional correlation study. The setting was the diabetes and endocrinology clinics at 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23329579
DOI: 10.1055/s-0032-1331695

Genes

DIO2

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The role of type II deiodinase polymorphisms in clinical management of hypothyroid patients treated with levothyroxine.PMID 23329579Read ↗

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The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Higher Body Mass Index and Fasting Glucose Levels: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

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The Physiological Functions and Polymorphisms of Type II DeiodinaseSemantic proximity Read ↗

Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.Semantic proximity Read ↗

Genetic abnormalities in thyroid hormone deiodinases.Semantic proximity Read ↗

Hypothyroid Patients Encoding Combined MCT10 and DIO2 Gene Polymorphisms May Prefer L-T3 + L-T4 Combination Treatment – Data Using a Blind, Randomized, Clinical StudySemantic proximity Read ↗

Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study.Semantic proximity Read ↗

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The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The -258A/G (SNP rs12885300) polymorphism of the human type 2 deiodinase gene is associated with a shift in the pattern of secretion of thyroid hormones following a TRH-induced acute rise in TSH.Semantic proximity Read ↗

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