Article

Single cell analyses of cancer cells identified two regulatorily and functionally distinct categories in differentially expressed genes among tumor subclones

2023-04-25

Abstract excerpt

To explore the feature of cancer cells and tumor subclones, we analyzed 101,065 single-cell transcriptomes from 12 colorectal cancer (CRC) patients and 92 single cell genomes from one of these patients. We found cancer cells, endothelial cells and stromal cells in tumor tissue expressed much more genes and had stronger cell-cell interactions than their counterparts in normal tissue. We identified copy number varia...

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Literature Corpus work: c86505e3-24ce-52f1-bc4c-f119a0d86d2a
DOI: 10.1101/2023.04.22.537630

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