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Genomic Analysis of Circulating Tumor Cells at the Single-Cell Level

2 Apr 2020

Abstract excerpt

Circulating tumor cells (CTCs) have a great potential for noninvasive diagnosis and real-time monitoring of cancer. A comprehensive evaluation of four whole genome amplification (WGA)/next-generation sequencing workflows for genomic analysis of single CTCs, including PCR-based (GenomePlex and Ampli1), multiple displacement amplification (Repli-g), and hybrid PCR- and multiple displacement amplification-based...

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PMID: 32247862
DOI: 10.1016/j.jmoldx.2020.02.013

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