Article

Direct RNA sequencing reveals selective remodeling of the host m6A epitranscriptome during Leishmania infection

2026-08-14

Abstract excerpt

N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA, yet its role in host responses to protozoan infection remains poorly explored. Here, we provide the first characterization of the host m6A epitranscriptome during Leishmania amazonensis infection, integrating clinical data, in vitro macrophage models, and direct RNA sequencing. Analysis of publicly available transcriptomic datasets from...

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Literature Corpus work: c013a3e8-db19-5971-883b-5fbb4f1ba6dd
DOI: 10.64898/2026.08.13.744690

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