Article

Monocyte-amplified transcriptional signatures of human diseases

2026-07-06

Abstract excerpt

<h4>ABSTRACT</h4> Blood-based biomarkers discovered by machine learning often lack disease specificity and cross-population robustness for clinical applications. We describe a biomarker discovery strategy that exploits monocytes as circulating sentinels to amplify disease-perturbed signals in blood. This strategy leverages monocyteMINER, a mechanistic transcriptional regulatory network inferred from monocyte tran...

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Literature Corpus work: 661f4321-a166-5deb-8f97-f2e635e54fea
DOI: 10.64898/2026.07.04.736372

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