Article

Electrophysiological maturation and increased excitability of human iPSC-derived neurons in <i>HTR2A</i> variant-related sleep bruxism

2021-01-27

Abstract excerpt

Sleep bruxism (SB) is a sleep-related movement disorder characterized by grinding and clenching of the teeth during sleep. We previously found a significant association between SB and a single nucleotide polymorphism (SNP), rs6313, in the neuronal serotonin 2A receptor gene ( HTR2A ), and established human induced pluripotent stem cell (hiPSC)-derived neurons from SB patients with a genetic variant. To elucidate...

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Literature Corpus work: c6fbb20e-cbd4-5d3e-8c2e-defd6df5b128
DOI: 10.1101/2021.01.26.428254

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