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Article

Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations.

Translational psychiatry - 6 Jul 2023

Hussein Yara, Tripathi Utkarsh, Choudhary Ashwani, Nayak Ritu, Peles David, Rosh Idan, Rabinski Tatiana, Djamus Jose, Vatine Gad David, Spiegel Ronen, Garin-Shkolnik Tali, Stern Shani

Abstract excerpt

Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of genetic variants were reported to be highly penetrant and causative of ASD. Many of these mutations cause comorbidities such as epilepsy and intellectual disabilities (ID). In this study, we measured cortical neurons derived from induced pluripotent...

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Identifiers

PMID: 37414777
DOI: 10.1038/s41398-023-02535-x
PMCID: PMC10326262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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