Article

Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytes

2025-10-24

Abstract excerpt

<h4>Summary</h4> Peripheral parasympathetic ganglia lie adjacent to their target organs; their dysfunction contributes to diseases like atrial fibrillation. Due to their challenging accessibility for primary culture, we provide a step-by-step protocol to generate parasympathetic neurons from human induced pluripotent stem cells (hiPSC). They reproduce numerous native physiological features: cholinergic and autono...

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Identifiers and source

Literature Corpus work: ef5797b9-6618-51ba-b37a-734c45338274
DOI: 10.1101/2025.10.23.684157

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