Article

Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations

2022-11-03

Abstract excerpt

Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-motor abnormal and repetitive behavior patterns. Over hundreds of genes and thousands of genetic variants were reported to be highly penetrant and causative of ASD. Many of these mutations cause comorbidities such as epilepsy and intellectual disabilities (ID). In this study, we measured cortical neurons derived from induced pluripotent s...

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Literature Corpus work: ef711608-acc2-55d6-8b20-5aca052b8587
DOI: 10.1101/2022.11.02.514882

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