Article
Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient.
Scientific reports - 26 Jul 2018
Ma Dongrui, Liu Zhenfeng, Loh Li Jun, Zhao Yongxing, Li Guang, Liew Reginald, Islam Omedul, Wu Jianjun, Chung Ying Ying, Teo Wee Siong, Ching Chi Keong, Tan Boon Yew, Chong Daniel, Ho Kah Leng, Lim Paul, Yong Rita Yu Yin, Panama Brian K, Kaplan Aaron D, Bett Glenna C L, Ware James, Bezzina Connie R, Verkerk Arie O, Cook Stuart A, Rasmusson Randall L, Wei Heming
Abstract excerpt
Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, yet its ionic mechanisms remain unclear due to a lack of cellular models. Here, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS patient (BrS1) to evaluate the roles of Na+ currents (INa) and transient outward K+ currents (Ito) in BrS induced action potential (AP) changes....
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