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Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutations

2023-01-04

Abstract excerpt

<title>Abstract</title><p>Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-motor abnormal and repetitive behavior patterns. Over 1000 genetic variants were reported to be highly penetrant and causative of ASD. Many of these mutations cause comorbidities such as epilepsy and intellectual disabilities (ID). In this study, we measured cortical neurons derived from induced pluripotent stem...

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Literature Corpus work
d8542145-c366-57c4-923b-78e1afff0543
DOI
10.21203/rs.3.rs-2358557/v1
Open publication

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Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-causing mutationsDOI 10.21203/rs.3.rs-2358557/v1
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