Article

ThX – A next-generation probe for the early detection of amyloid aggregates

2019-07-24

Abstract excerpt

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s are associated with protein misfolding and aggregation. Recent studies suggest that the small, rare and heterogeneous oligomeric species, formed early on in the aggregation process, may be a source of cytotoxicity. Thioflavin T (ThT) is currently the gold-standard fluorescent probe for the study of amyloid proteins and aggregation processes. However, t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6f17082-293f-5981-b18f-66f268424230
DOI: 10.1101/713594

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ThX – A next-generation probe for the early detection of amyloid aggregatesDOI 10.1101/713594Read

Redesign of a thioflavin-T-binding protein with a flat β-sheet to evaluate a thioflavin-T-derived photocatalyst with enhanced affinity.Semantic proximity Read

Residue-Specific Binding Mechanisms of Thioflavin T to a Surface of Flat β-Sheets within a Peptide Self-Assembly Mimic.Semantic proximity Read

Q-DOAS: A Proximity Quenching Assay for Real-Time Detection of Early Protein Aggregation EventsSemantic proximity Read

Novel Pentameric Thiophene Derivatives for <i>in Vitro</i> and <i>in Vivo</i> Optical Imaging of a Plethora of Protein Aggregates in Cerebral AmyloidosesSemantic proximity Read

Conformational dynamics of Tau in the cell quantified by an intramolecular FRET biosensor in physiological and pathological contextSemantic proximity Read

Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregatesSemantic proximity Read

A FRET Sensor for Non‐Invasive Imaging of Amyloid Formation in VivoSemantic proximity Read

Photo-excited Toluidine Blue Inhibits Full-Length Tau Aggregation in Alzheimer’ DiseaseSemantic proximity Read

Biochemical and biophysical features of disease-associated tau mutants V363A and V363I.Semantic proximity Read

Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells.Semantic proximity Read

Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cellsSemantic proximity Read

N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer’s Disease β-Amyloid Aggregation in Living CellsSemantic proximity Read