Article

Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates

2023-06-29

Abstract excerpt

The misfolding and aggregation of protein is a characteristic of many neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. The wide range of sizes and structures of oligomers and fibrils generated have previously been studied using single-molecule and super-resolution microscopy. These methods, however, tend to rely on the use of either directly labeled protein, or on the addition of non-spe...

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Literature Corpus work: 47519dfc-f59c-5585-b951-0a8444b250f1
DOI: 10.1101/2023.06.27.546642

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