N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer’s Disease β-Amyloid Aggregation in Living Cells

Abstract excerpt

Formation of amyloid fibrils by amyloid-β peptide (Aβ) is an important step in Alzheimer's disease (AD) progression. Screening and designing of new molecules which can monitor the amyloidosis process especially in cells are diagnostically and therapeutically important. Utilizing Thioflavin T (ThT), the commonly used amyloid dye, is the most standardized way to monitor amyloid. However, with the green fluorescence...

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