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Novel Pentameric Thiophene Derivatives for <i>in Vitro</i> and <i>in Vivo</i> Optical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

22 Jul 2009

Abstract excerpt

Molecular probes for selective identification of protein aggregates are important to advance our understanding of the molecular pathogenesis underlying cerebral amyloidoses. Here we report the chemical design of pentameric thiophene derivatives, denoted luminescent conjugated oligothiophenes (LCOs), which could be used for real-time visualization of cerebral protein aggregates in transgenic mouse models of...

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PMID: 19624097
DOI: 10.1021/cb900112v

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