Article
Biochemical and biophysical features of disease-associated tau mutants V363A and V363I.
Biochimica et biophysica acta. Proteins and proteomics - 1 Mar 2022
De Luigi Ada, Colombo Laura, Russo Luca, Ricci Caterina, Bastone Antonio, Cimini Sara, Tagliavini Fabrizio, Rossi Giacomina, Cantù Laura, Del Favero Elena, Salmona Mario
Abstract excerpt
The comprehension of pathogenetic mechanisms in tauopathy-associated neurodegenerative diseases can be improved by the knowledge of the biochemical and biophysical features of mutated tau proteins. Here, we used the full-length, wild-type tau, the V363A and V363I mutated species, associated with pathology, and the P301L mutated tau as a benchmark. Using several techniques, including small-angle X-ray scattering,...
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