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Article

Redesign of a thioflavin-T-binding protein with a flat β-sheet to evaluate a thioflavin-T-derived photocatalyst with enhanced affinity.

International journal of biological macromolecules - 1 Jun 2024

Miura Yuina, Namioka Sae, Iwai Atsushi, Yoshida Norio, Konno Hiroyuki, Sohma Youhei, Kanai Motomu, Makabe Koki

Abstract excerpt

Amyloids, proteinous aggregates with β-sheet-rich fibrils, are involved in several neurodegenerative diseases such as Alzheimer's disease; thus, their detection is critically important. The most common fluorescent dye for amyloid detection is thioflavin-T (ThT), which shows on/off fluorescence upon amyloid binding. We previously reported that an engineered globular protein with a flat β-sheet, peptide...

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PMID: 38697433
DOI: 10.1016/j.ijbiomac.2024.131992

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