Article

AMPK mediates early activation of the unfolded protein response through a positive feedback loop in palmitate-treated muscle cells

2021-10-13

Abstract excerpt

Activation of the unfolded protein response (UPR) is closely associated with the pathogenesis of many metabolic diseases including obesity and type 2 diabetes. There is increasing evidence for the interdependence of the UPR and metabolic signaling pathways. The AMP-activated protein kinase (AMPK) signaling pathway controls energy balance in eukaryotes. The aim of this study was to investigate the possible interact...

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Literature Corpus work: c6ee5473-a0a4-5e8d-bb85-df324c9d8088
DOI: 10.1101/2021.10.12.464004

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