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Article

AMP‐activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction–induced Longevity

1 Jul 2009

Abstract excerpt

Aging is regulated by modifications in single genes and by simple changes in the environment. The signaling pathway connecting insulin to FoxO transcription factors integrates environmental stimuli to regulate lifespan. FoxO transcription factors are directly phosphorylated in response to insulin/growth factor signaling by the protein kinase Akt, thereby causing their sequestration in the cytoplasm. In the...

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PMID: 19686213
DOI: 10.1111/j.1749-6632.2009.04019.x

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