Article
Partial Inhibition of Glycolysis Reduces Atherogenesis Independent of Intraplaque Neovascularization in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 May 2020
Perrotta Paola, Van der Veken Bieke, Van Der Veken Pieter, Pintelon Isabel, Roosens Laurence, Adriaenssens Elias, Timmerman Vincent, Guns Pieter-Jan, De Meyer Guido R Y, Martinet Wim
Abstract excerpt
OBJECTIVE: Intraplaque neovascularization is an important feature of unstable human atherosclerotic plaques. However, its impact on plaque formation and stability is poorly studied. Because proliferating endothelial cells generate up to 85% of their ATP from glycolysis, we investigated whether pharmacological inhibition of glycolytic flux by the small-molecule 3PO (3-[3-pyridinyl]-1-[4-pyridinyl]-2-propen-1-one)...
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