Isoginkgetin stabilizes atherosclerotic plaques by targeting NR4A2 to modulate the PPAR signaling pathway and reprogram ceramide metabolism, thereby inhibiting vascular smooth muscle cell phenotypic transformation.

Abstract excerpt

Atherosclerosis is the fundamental pathological basis of major adverse cardiovascular events, and vascular smooth muscle cell (VSMC) phenotypic transition represents a key determinant of plaque vulnerability. Isoginkgetin (IGK), a naturally derived biflavonoid from Ginkgo biloba, has exhibited beneficial roles in lipid metabolism and vascular function; however, its precise mechanism in plaque stabilization...

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