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Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr-/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2017

Samsoondar Joshua P, Burke Amy C, Sutherland Brian G, Telford Dawn E, Sawyez Cynthia G, Edwards Jane Y, Pinkosky Stephen L, Newton Roger S, Huff Murray W

Abstract excerpt

OBJECTIVE: Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol-lowering compound. In animals, bempedoic acid targets the liver where it inhibits cholesterol and fatty acid synthesis through inhibition of ATP-citrate lyase and through activation of AMP-activated protein kinase. In this study, we tested the hypothesis that bempedoic acid...

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Source

Identifiers

PMID: 28153881
DOI: 10.1161/ATVBAHA.116.308963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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