Article

Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice

2022-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Regression of atherosclerosis is impaired in diabetes. However, the factors mediating this effect remain incomplete. We identified Protein Arginine Methyltransferase 2 (PRMT2) as a protein whose expression in macrophages is reduced in hyperglycemia and diabetes. PRMT2 catalyzes arginine methylation to target proteins to modulate gene expression. Because PRMT2 expression is reduced in cells in hy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7386aaa2-2682-566d-9b05-e2e2d768169b
DOI: 10.1101/2022.04.15.488480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic miceDOI 10.1101/2022.04.15.488480Read

Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.Semantic proximity Read

IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.Semantic proximity Read

Inhibition of transglutaminase 2 reduces efferocytosis in human macrophages: Role of CD14 and SR-AI receptors.Semantic proximity Read

SIRT2 decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by modulating macrophage polarization.Semantic proximity Read

Epigenetic mechanisms of macrophage activation in type 2 diabetesSemantic proximity Read

Resolvin D2-GPR18 Signaling on Myeloid Cells Limits Plaque NecrosisSemantic proximity Read

The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophagesSemantic proximity Read

The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound RepairSemantic proximity Read

Monocytic MKP-1 is a Sensor of the Metabolic Environment and Regulates Function and Phenotypic Fate of Monocyte-Derived Macrophages in Atherosclerosis.Semantic proximity Read

GATA2 Mediates Macrophage Proliferation During AtherosclerosisSemantic proximity Read

BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal HematopoiesisSemantic proximity Read

PRMT1 Is Required for the Maintenance of Mature β-Cell IdentitySemantic proximity Read