Article

Comparative landscape of genetic dependencies in human and chimpanzee stem cells

2023-03-20

Abstract excerpt

Comparative studies of great apes provide a window into our evolutionary past, but the extent and identity of cellular differences that emerged during hominin evolution remain largely unexplored. We established a comparative loss-of-function approach to evaluate whether changes in human cells alter requirements for essential genes. By performing genome-wide CRISPR interference screens in human and chimpanzee pluri...

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Literature Corpus work: c650393f-b58c-595e-bc63-e6302b7bde14
DOI: 10.1101/2023.03.19.533346

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