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Article

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.

Cells - 21 Oct 2022

Rosa Juao-Guilherme, Hamel Katherine, Sheeler Carrie, Borgenheimer Ella, Gilliat Stephen, Soles Alyssa, Ghannoum Ferris J, Sbrocco Kaelin, Handler Hillary P, Rainwater Orion, Kang Ryan, Cvetanovic Marija

Abstract excerpt

While astrocyte heterogeneity is an important feature of the healthy brain, less is understood about spatiotemporal heterogeneity of astrocytes in brain disease. Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by a CAG repeat expansion in the gene Ataxin1 (ATXN1). We characterized astrocytes across disease progression in the four clinically relevant brain regions,...

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PMID: 36291186
DOI: 10.3390/cells11203323
PMCID: PMC9599982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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