Article

Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar ataxia type 1 mice

2021-09-15

Abstract excerpt

While astrocyte heterogeneity is an important feature of the healthy brain, less is understood about spatiotemporal heterogeneity of astrocytes in brain disease. Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by a CAG repeat expansion mutation in the gene Ataxin1 ( ATXN1 ). We characterized astrocytes across disease progression in the four clinically relevant brain regions...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 023537f6-b69d-5333-a9b3-f2f7c082daee
DOI: 10.1101/2021.09.13.460129

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial and temporal diversity of astrocyte phenotypes in Spinocerebellar ataxia type 1 miceDOI 10.1101/2021.09.13.460129Read

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice.Semantic proximity Read

Molecular basis of astrocyte diversity and morphology across the CNS in health and diseaseSemantic proximity Read

Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective.Semantic proximity Read

Diversity of astrocyte functions and phenotypes in neural circuits.Semantic proximity Read

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.Semantic proximity Read

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in NeurodegenerationSemantic proximity Read

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in NeurodegenerationSemantic proximity Read

Striatal compartmentalization and clustering of different subtypes of astrocytes is altered in the zQ175 Huntington’s disease mouse modelSemantic proximity Read

Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)‐regulated glial proliferationSemantic proximity Read

Region-specific homeostatic identity of astrocytes is essential for defining their reactive phenotypes following pathological insultsSemantic proximity Read

Astrocyte Heterogeneity: Impact to Brain Aging and DiseaseSemantic proximity Read

Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse modelSemantic proximity Read