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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype

2025-03-31

Abstract excerpt

<title>Abstract</title> <p>Despite efforts to understand breast cancer biology, metastatic disease remains a clinical challenge. Identifying suppressors of breast cancer progression and mechanisms of transition to more invasive phenotypes could provide game changing therapeutic opportunities. Transcriptional deregulation is central to all malignancies, highlighted by the extensive reprogramming of regulatory elem...

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Literature Corpus work
7b4b33cf-8073-57cb-bee8-6b4be6362e5d
DOI
10.21203/rs.3.rs-6240646/v1
Open publication

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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotypeDOI 10.21203/rs.3.rs-6240646/v1
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