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Article

NF-κB Epigenetic Attractor Landscape Drives Breast Cancer Heterogeneity

2024-07-14

Abstract excerpt

<h4>ABSTRACT</h4> Heterogeneity in breast cancer (BC) subtypes contributes to therapy resistance and recurrence. Subtype heterogeneity arises from stochastic genetic and epigenetic changes, phenotypic plasticity, and microenvironment-driven selection during tumor evolution. Here, we investigate how NF-κB epigenetic variability contributes to HER2 + BC progression. Using RNA-seq, we quantified NF-κB, TWIST1, SIP1...

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Literature Corpus work
34b7d9a4-6dfb-53bf-95f8-fc10e96c25fb
DOI
10.1101/2024.07.10.602798
Open publication

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NF-κB Epigenetic Attractor Landscape Drives Breast Cancer HeterogeneityDOI 10.1101/2024.07.10.602798
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