Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.

doi:10.1007/s00018-025-05913-4

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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.

Cellular and molecular life sciences : CMLS - 13 Nov 2025

Arcuschin Camila D, Kahrizi Kamin, Sayaman Rosalyn W, DiBenedetto Carolina, Salaberry Pedro J, Pirker Roxana, Shen Yizhuo, Zakraoui Ons, Schwarzer Cecilia, Scapozza Alessandro, Caruso Joseph A, Betancur Paola, Saba Julie D, Coppé Jean-Philippe, Barcellos-Hoff Mary-Helen, Kappes Dietmar, van 't Veer Laura, Schor Ignacio E, Muñoz Denise P

Abstract excerpt

Despite efforts to understand breast cancer biology, metastatic disease remains a clinical challenge. Identifying suppressors of breast cancer progression and mechanisms of transition to more invasive phenotypes could provide game changing therapeutic opportunities. Transcriptional dysregulation is central to all malignancies, highlighted by the extensive reprogramming of regulatory elements that underlie...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41231242
DOI: 10.1007/s00018-025-05913-4
PMCID: PMC12615902

Genes

CD4
ZBTB7B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4+ cell lineage commitment factor, as a master regulator that restricts breast cancer cells to a luminal non-migratory phenotype.PMID 41231242Read ↗

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