Article
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.
Development (Cambridge, England) - 1 Feb 2017
Planutis Antanas, Xue Li, Trainor Cecelia D, Dangeti Mohan, Gillinder Kevin, Siatecka Miroslawa, Nebor Danitza, Peters Luanne L, Perkins Andrew C, Bieker James J
Abstract excerpt
Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter...
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