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Article

Characterization of erythroferrone oligomerization and its impact on BMP antagonism.

The Journal of biological chemistry - 1 Jan 2024

Mast Eleanor M, Leach Edmund A E, Thompson Thomas B

Abstract excerpt

Hepcidin, a peptide hormone that negatively regulates iron metabolism, is expressed by bone morphogenetic protein (BMP) signaling. Erythroferrone (ERFE) is an extracellular protein that binds and inhibits BMP ligands, thus positively regulating iron import by indirectly suppressing hepcidin. This allows for rapid erythrocyte regeneration after blood loss. ERFE belongs to the C1Q/TNF-related protein family and is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37949218
DOI: 10.1016/j.jbc.2023.105452
PMCID: PMC10772735

Genes

ERFE
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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